中科院再生生物學(xué)重點(diǎn)實(shí)驗(yàn)室青年學(xué)者進(jìn)階培訓(xùn)計(jì)劃之青年論壇:Transposable elements activation triggers necroptosis in mouse embryonic stem cells
主講人：吳凱昕 博士
時(shí)間：5月31日 15:30（星期三）
地點(diǎn)：E228
主持人：楊雪潔 博士
Achievement introduction:
Transposable elements activation triggers necroptosis in mouse
embryonic stem cells；Deficiency of the histone H3K9 methyltransferase SETDB1 induces RIPK3-dependent necroptosis in mouse embryonic stem cells (mESCs). However, how necroptosis pathway is activated in this process remains elusive. Here we report that the reactivation of transposable elements (TEs) upon SETDB1 knockout is responsible for the RIPK3 regulation through both cis and trans mechanisms. IAPLTR2_Mm and MMERVK10c-int, both of which are suppressed by SETDB1-dependent H3K9me3, act as enhancer-like cis- regulatory elements and their RIPK3 nearby members enhance RIPK3 expression when SETDB1 is knockout. Moreover, reactivated endogenous retroviruses generate excessive viral mimicry, which promotes necroptosis mainly through Z-DNA-binding protein 1(ZBP1). These results indicate TEs play an important role in regulating necroptosis.
