發(fā)布時間：2019-10-15
題目：Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming
主講人：陳可實 副研究員
時間：2019年10月18日 15：30
地點：第一會議室A430
主持人：郭宜平 副研究員
Achievement introduction: Chromatin relaxation is required for generation of pluripotent stem cells, but how factor‐dependent chromatin opening is instructed remains poorly understood. Here, epigenetic profiling reveals Oct4 as a pioneer factor that loosens heterochromatin and cooperates with Klf4 and other chromatin remodellers during reprogramming.
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