發(fā)布時間：2019-03-01
題目：Coronavirus Fusion Triggering Mechanism Revealed by Electron Microscopy
主講人：熊曉犁(MRC Laboratory of Molecular Biology, Cambridge, UK)
時間：2019年3月7日 11:00-12:00am
地點：廣州生物醫(yī)藥與健康研究院（A326）
主持人：何俊 研究員
In this talk, Dr.Xiong will present a cryo-EM structure of the SARS-CoV S glycoprotein in complex with a neutralising antibody isolated from a SARS survivor, this structure reveals an un-expected spike protein conformation that represents a fusogenic intermediate state. This intermediate state is shown to be induced by antibody binding to the S receptor binding domain. Inspired by this structure, we confirmed, by a series of biochemical experiments, that binding of the receptor rather than pH change or proteolytic activation serves the fusion trigger for SARS-CoV and possibly other coronaviruses. This result also suggests antibodies target the S receptor binding region may be advantageous due to its potential of inducing premature fusion triggering
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